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International Journal of Bioprinting                                Bioactive scaffold for necrosis bone repair




            Acknowledgments                                    2.   Cui Q, Jo WL, Koo KH, et al. ARCO consensus on the
                                                                  pathogenesis of non-traumatic osteonecrosis of the femoral
            The authors would like to thank the Central Laboratory   head. J Korean Med Sci. 2021;36(10):e65.
            of Jiangsu Province Hospital of Chinese Medicine and the      doi: 10.3346/jkms.2021.36.e65
            International Chinese-Belorussian Scientific Laboratory   3.   Chen K, Liu Y, He J, et al. Steroid-induced osteonecrosis of the
            on  Vacuum-Plasma  Technology,  Nanjing  University  of   femoral head reveals enhanced reactive oxygen species and
            Science and Technology, for their help.               hyperactive osteoclasts. Int J Biol Sci. 2020;16(11):1888–1900.
                                                                  doi: 10.7150/ijbs.40917
            Funding
                                                               4.   Xue P, Chen H, Xi H, et al. Magnesium dopped calcium-
            This research was funded by National Natural Science   fluoride/icaritin composite multi-layer coating functionalized
            Foundation of China (No. 82074471), Jiangsu Provincial   3D printed β-TCP scaffold inducessustained bone regeneration
            Commission of Health and Family Planning (No.         in a rabbit model. Mater Des. 2022;223(111156):111156.
            K2019027), Priority Academic Program Development of      doi: 10.1016/j.matdes.2022.111156
            Jiangsu Higher Education Institutions (No. 035062005001),   5.   Yuan P, Liu X, Du B, Sun GQ, Wang X, Lin XY. Mid- to
            and Jiangsu Graduate Practice and Innovation Plan (No.   long-term results of modified avascular fibular grafting for
            SJCX22_0769).                                         ONFH. J Hip Preserv Surg. 2021;8(3):274–281.
                                                                  doi: 10.1093/jhps/hnab046
            Conflict of interest                               6.   Bavya DK, Lalzawmliana V, Saidivya M, Kumar V, Roy M,
            The authors declare no conflicts of interest.         Nandi SK. Magnesium phosphate bioceramics for bone
                                                                  tissue engineering. Chem Rec. 2022;22(11):e202200136.
            Author contributions                                  doi: 10.1002/tcr.202200136

            Conceptualization:  Xiaoxue  Tan,  Hongzhong  Xi,  7.   Nabiyouni M, Brückner T, Zhou H, Gbureck U, Bhaduri SB.
                                                                  Magnesium-based bioceramics in orthopedic applications.
               Changyuan Gu                                       Acta Biomater. 2018;66(2018):23–43.
            Formal analysis: Hao Chen, Shuai He, Changyuan Gu      doi: 10.1016/j.actbio.2017.11.033
            Funding acquisitions: Bin Du, Xin Liu
            Investigation: Peng Xue, Xiaoxue Tan, Changyuan Gu  8.   Baldwin P, Li DJ, Auston DA, Mir HS, Yoon RS, Koval KJ.
            Methodology: Guangquan Sun, Xiaohong Jiang, Shuai He  Autograft, allograft, and bone graft substitutes: Clinical
            Resources: Guangquan Sun, Xiaoxue Tan, Hongzhong Xi   evidence and indications for use in the setting of orthopaedic
                                                                  trauma surgery. J Orthop Trauma. 2019;33(4):203–213.
            Supervision: Xin Liu, Bin Du                          doi: 10.1097/BOT.0000000000001420
            Visualization: Xiaohong Jiang, Hao Chen,
            Writing – original draft: Peng Xue, Bin Du         9.   Zhou Q, Su X, Wu J, et al. Additive manufacturing of
            Writing – review & editing: Xin Liu, Peng Xue         bioceramic  implants for restoration bone engineering:
                                                                  Technologies, advances, and future perspectives.  ACS
            Ethics approval and consent to participate            Biomater Sci Eng. 2023;9(3):1164–1189.
                                                                  doi: 10.1021/acsbiomaterials.2c01164
            This study was approved by the Ethics Committee of   10.  Chen X, Tan B, Bao Z, et al. Enhanced bone regeneration
            The Affiliated Hospital of Nanjing University (approval   via spatiotemporal and controlled delivery of a genetically
            number: 2021 DW-12-02).                               engineered BMP-2 in a composite hydrogel.  Biomaterials.
                                                                  2021;277(2021):121117.
            Consent for publication                               doi: 10.1016/j.biomaterials.2021.121117
            Not applicable.                                    11.  Hong  KS,  Kim  EC,  Bang  SH,  et  al.  Bone  regeneration
                                                                  by bioactive hybrid membrane containing FGF2 within
            Availability of data                                  rat calvarium.  J Biomed Mater Res A. 2010;94(4):
                                                                  1187–1194.
            The data that support the findings of this study are available      doi: 10.1002/jbm.a.32799
            from the corresponding author upon reasonable request.
                                                               12.  León-Del-Río A. Biotin in metabolism, gene expression, and
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            1.   Zhao D, Zhang F, Wang B, et al. Guidelines for clinical diagnosis   13.  Bain SD, Newbrey JW, Watkins BA. Biotin deficiency may
               and treatment of osteonecrosis of the femoral head in adults   alter tibiotarsal bone growth and modeling in broiler chicks.
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               doi: 10.1016/j.jot.2019.12.004                     doi: 10.3382/ps.0670590

            Volume 10 Issue 1 (2024)                       444                          https://doi.org/10.36922/ijb.1152
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