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Sandra Sánchez-Salcedo, Montserrat Colilla, Isabel Izquierdo-Barba, et al.

This feature permits incorporating biologically active structural properties of biomaterial surfaces permits
molecules, such as therapeutic drugs and osteoinduc- providing bioceramic and metallic substrates antibac-
tive agents, during the manufacture of the scaffold. terial properties by notably reducing bacterial adhe-
Thus, 3D scaffolds based in demineralized bone matrix sion and biofilm formation compared to bare sub-
(DBM) containing nanocrystalline silicon doped hy- strates. The application of these approaches to 3D
droxyapatite (HA) and PCL have been fabricated [99] . scaffolds augur promising opportunities in the field of
bone tissue engineering.
3.2 Selective Laser Based Techniques
Conflict of Interest and Funding
Among the most used laser-assisted additive manu-
facturing are the SLS and SLM techniques [100] . These The authors declare no conflict of interest. The authors
techniques involved selective use of a laser to build up would like to acknowledge the Ministry of Economy
a model layer by layer from a fine powder bed (Figure and Competitiveness (MINECO), Spain, for funding
4B). The fine powder particles adhere and sinter when through projects MAT2012-35556 and CSO2010-
illuminated by a laser beam. Each layer is scanned 11384-E (Agening Network of Excellence).
according to its corresponding cross-section as calcu-
lated from the CAD model. The immediate advantage References
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