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Weiguang Wang, Guilherme Ferreira Caetano, Wei-Hung Chiang, et al.

It was also observed that pristine graphene slightly brication and evaluation of PCL/graphene scaffolds for
reduces the contact angle, thus increasing the cell- bone regeneration.
scaffold affinity and cell viability/proliferation. These 5. Oryan A, Alidadi S, Moshiri A, et al., 2014, Bone re-
results suggest that PCL/pristine graphene scaffolds generative medicine: classic options, novel strategies,
are promising biomaterial for bone tissue engineering and future directions. Journal of Orthopaedic Surgery
applications. and Research, vol.9(1): 18.
http://dx.doi.org/10.1186/1749-799X-9-18
Conflict of Interest and Funding 6. Denry I and Kuhn L T, 2016, Design and characteriza-
tion of calcium phosphate ceramic scaffolds for bone
No conflict of interest was reported by the authors. tissue engineering. Dental Materials, vol.32(1): 43–53.
Mr. Weiguang Wang wishes to acknowledge the http://dx.doi.org/10.1016/j.dental.2015.09.008
School of Mechanical, Aerospace and Civil Engineer- 7. Fiedler T, Videira A C, Bártolo P, et al., 2013, On the
ing, University of Manchester, for the financial sup- mechanical properties of PLC–bioactive glass scaffolds
port on his PhD project. fabricated via BioExtrusion. Materials Science and En-
Mr. Guilherme Ferreira Caetano wishes to ackno- gineering: C, vol.57: 288–293.
wledge the financial support received from FAPESP, http://dx.doi.org/10.1016/j.msec.2015.07.063
Brazil (Process 2014/23662-1). 8. Sousa I, Mendes A, Pereira R F, et al., 2014, Collagen
This work was partially performed within the fra- surface modified poly (ε-caprolactone) scaffolds with
mework of the SKELGEN project – Establishment of improved hydrophilicity and cell adhesion properties.
a cross continent consortium for enhancing regenera- Materials Letters, vol.134: 263–267.
http://dx.doi.org/10.1016/j.matlet.2014.06.132
tive medicine in skeletal tissues (Marie Curie Action, 9. Santos A R C, Almeida H A and Bártolo P J, 2013, Ad-
International Research Staff Exchange Scheme (IR- ditive manufacturing techniques for scaffold-based car-
SES) – Project reference: 318553). tilage tissue engineering. Virtual and Physical Proto-
Acknowledgements typing, vol.8(3): 175–186.
http://dx.doi.org/10.1080/17452759.2013.838825
The authors would like to acknowledge Mr. David 10. Bartolo P J, Kruth J P, Silva J, et al., 2012, Biomedical
Mortimer for the technical support on mechanical tests, production of implants by additive electro-chemical and
Mr. William Stephen Ambler for his technical support physical processes. CIRP Annals – Manufacturing Tech-
on SEM operation, Mr. Ruben Pereira for his support nology, vol.61(2): 635–655.
http://dx.doi.org/10.1016/j.cirp.2012.05.005
on the contact angle measuring procedure, Prof. Nic- 11. Bártolo P J, Chua C K, Almeida H A, et al., 2009, Bio-
holas Turner for his kind support on the plate reader manufacturing for tissue engineering: present and future
and Mr. Ningning Zhu for his assistance on chemicals.
trends. Virtual and Physical Prototyping, vol.4(4): 203–
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