Page 23 - IJB-10-4

International Journal of Bioprinting PAI for 3D bioprinted constructs

due to its strong absorption in the NIR region. Scaffolds chondrosarcoma resection (Figure 11a). This hydrogel
84
fabricated using Alg-PDA as an ink for 3D bioprinting comprises a methacrylate anhydride-modified sericin
showcased excellent flexibility and modulus similar to (SerMA) solution mixed with procyanidin (PC)-loaded
those of normal breast tissues, facilitating the adhesion PDA-modified ZIF-8 (PC@ZIF-8@PDA) nanoparticles.
and proliferation of normal breast epithelial cells. PDA This composition imparts the hydrogel with both biological
nanoparticles have been used as PAI contrast agents due activity and photothermal effect. The photothermal
to their strong NIR absorbance. As expected, the Alg- effect has been demonstrated to exhibit antitumor and
PDA scaffolds exhibited strong PA signals both in vivo antibacterial properties and promote the repair of articular
and in vitro. Moreover, the PA signal diminished with cartilage defects in vivo. Moreover, when combined
time, suggesting that PAI could be used to evaluate the in with NIR light, photothermal action has been shown
vivo performance of the Alg-PDA scaffolds (Figure 10b). to eliminate chondrosarcoma cells and bacteria such as
Overall, the study findings suggest that 3D printing using Staphylococcus aureus and Escherichia coli. The hydrogel
Alg-PDA is a promising approach for the treatment of also exhibited antioxidant activity and was biocompatible.
nonsurgical breast cancer. The photo-crosslinked PC@ZIF-8@PDA/SerMA hydrogel
The utilization of multifunctional hydrogels can was successfully used to repair cartilage defects in rabbit
be assessed using PAI, which involves the mixing of and mouse skin burning wounds. The team employed a
various substances. Zhu et al. developed a versatile 3D bioprinter to determine the feasibility of the hydrogel
hydrogel which has potential applications in the clinical as a bioink in 3D bioprinting, and printed a hydrogel
treatment of chondrosarcoma and tissue repair following encapsulating chondrocytes. The ability of the hydrogel to

Figure 10. 3D-bioprinted alginate-polydopamine (Alg-PDA) scaffolds for the nonsurgical treatment of breast cancer. (a) 3D-printed scaffold incorporating
photothermal therapy, made of Alg-PDA. (b) Photoacoustic imaging of Alg scaffolds and Alg-PDA scaffolds before (in vitro) and after implantation at
tumor sites in mice for 2 and 9 days. The images are reproduced with permission from. 83

Volume 10 Issue 4 (2024) 15 doi: 10.36922/ijb.3448