Page 91 - IJB-10-4

International

Journal of Bioprinting

REVIEW ARTICLE
Antibacterial compounds-incorporated

functional biomaterials for chronic wound
healing application via 3D bioprinting:

The mechanism of action

Nur Izzah Md Fadilah 1† id , Nur Aifa Asyhira Khairul Nizam ,
1†
and Mh Busra Fauzi *
1,2 id
1 Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti
Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia
2 Advance Bioactive Materials-Cells (Adv-BioMaC) UKM Research Group, Universiti Kebangsaan
Malaysia, 43600 Bangi, Selangor, Malaysia
(This article belongs to the Special Issue: Biomimetic and bioinspired printed structures)

Abstract

Wounds represent a critical issue in the healthcare industry since they are highly
susceptible to infections that in turn lead to more serious complications. With
bacterial infections gradually growing to be a challenge to wound healing, fighting
bacterial resistance has become one of the important pillars of addressing issues
faced by healthcare personnel. Thus, gaining an understanding of the distinct stages
of wound healing is vital to further improve relevant therapies incorporating the
† These authors contributed equally
to this work. application of antibacterial compounds. Recently, three-dimensional (3D)-printed
functional biomaterials have emerged as an alternative treatment or potential
*Corresponding author:
Mh Busra Fauzi carriers incorporating relevant antibacterial agents, offering a new approach to skin
(fauzibusra@ukm.edu.my) tissue engineering. Novel strategies for skin tissue engineering are grounded in
Citation: Fadilah NIM, the integration of bioactive ingredients and antibacterial agents into biomaterials
Khairul Nizam NAA, Fauzi MB. with different morphologies to improve cell behaviors and promote wound healing
Antibacterial compounds- by preventing bacterial colonization. This paper reviews the function of natural
incorporated functional biomaterials
for chronic wound healing and synthetic polymers, effects of antibacterial properties, and cell interactions
application via 3D bioprinting: in terms of the wound healing process. Extensive research has demonstrated that
The mechanism of action. 3D functional biomaterials exert their therapeutic effects through multifaceted
Int J Bioprint. 2024;10(4):3372.
doi: 10.36922/ijb.3372 pathways, including but not limited to, modulating inflammation, facilitating tissue
regeneration, promoting cell proliferation, enhancing angiogenesis, and controlling
Received: April 7, 2024 infection. This review also provides general insights into the elegant design for 3D
Accepted: May 17, 2024
Published Online: July 5, 2024 scaffold and further refinement of wound dressing.
Copyright: © 2024 Author(s).
This is an Open Access article Keywords: Antibacterial properties; Biomaterials; 3D printing; Mechanism of action;
distributed under the terms of the
Creative Commons Attribution Wound healing
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited.
1. Introduction
Publisher’s Note: AccScience
Publishing remains neutral with Accounting for approximately 16% of the total body weight, the skin constitutes the
regard to jurisdictional claims in largest part of the human body. Primarily, the skin functions as the body’s first line of
1
published maps and institutional
affiliations. defense against harmful external elements and is essential for maintaining homeostasis.

Volume 10 Issue 4 (2024) 83 doi: 10.36922/ijb.3372