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International Journal of Bioprinting Biomaterials with antibacterial agents

Figure 2. Incorporation of antibacterial compounds into biomaterials to promote wound healing. The figure was created with BioRender.com.

to the application of 3D bioprinting in wound healing and natural biomaterials. Natural polymers are non-toxic, more
skin regeneration. This technology’s adaptability allows biocompatible, and have outstanding biodegradability. 29,30
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for precise printing with a high spatial precision and high Some of the most commonly used biomaterials include
resolution. Moreover, 3D cell printing can be applied to collagen, gelatin. chitosan, hyaluronic acid, and alginate,
the evaluation of prospective therapeutic medications and which are either used alone or in combination. These
therapies to promote wound healing, as well as to wound polymers are all safe, biocompatible, and biodegradable,
healing assays to study the potential pathways involved in making them ideal for a wide range of tissue engineering
wound repair. “Bioprinting” is a technique based on 3D applications. The origin of these materials also makes them
printing, utilizing printers to deposit biologically suitable suitable for the substitution of natural ECM structural
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materials and bioprintable materials along with cells components and skin cellular background.
known as “bioinks.” The use of natural and/or synthetic It is crucial that the 3D-printed biomaterials can
biomaterials in 3D printing offers appealing advantages for afford an environment that is favorable to normal skin
enhanced wound treatment, including biocompatibility cell migration and proliferation during wound healing.
between the material and the wound, biodegradation Additionally, this technology permits the creation of
of the printed items, and low or non-toxicity effects. wound dressings that are precisely tailored and filled
Furthermore, dressings created with 3D bioprinting with different substances to expedite the healing process.
technology can reduce microbial infections by maintaining Since a variety of biopolymers may be used, this method
an oxygenated and moist microenvironment. 27 is therefore a promising way to build various drug delivery
systems that will aid in wound healing, such as artificial
2.1. Natural biopolymers used in skin skins, microneedles, biofilms, and scaffolds. Each type of
tissue engineering polymer is described in detail along with one of the recent
Created by living cells, natural biopolymers have the power applications in Table 1.
to control a wide range of biological functions within an
organism’s body. Natural biopolymers exist in large 2.2. Synthetic biopolymers used in skin
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abundance in ECM and have exceptional biocompatibility tissue engineering
and excellent bioactivity. Directly sourced naturally Synthetic biopolymers, instead of natural biomaterials,
renewable resources including forestry products, tunicates, can be used in skin tissue engineering and regenerative
grasses, crustaceans, and arthropods are good sources of medicine. Extensive studies on the utilization of synthetic

Volume 10 Issue 4 (2024) 86 doi: 10.36922/ijb.3372