Page 76 - IJB-10-5

International

Journal of Bioprinting

REVIEW ARTICLE
Emerging frontiers in 3D bioprinting: Harnessing

decellularized matrix bioink for advancements in
musculoskeletal tissue engineering

Peilin Li 1† id , Xixin Li 1† id , Guosheng Tang 2 id , Zongke Zhou 3 id , and Zeyu Luo *
3 id
1 State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research
Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology,
Sichuan University, Chengdu, Sichuan, China
2 Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target
and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School
of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University,
Guangzhou, Guangdong, China
3 Department of Orthopedics, West China School of Medicine, West China Hospital, Sichuan
University, Chengdu, Sichuan, China
(This article belongs to the Special Issue: Advancements in 3D Printing, Microfluidics, and their Integrated
Applications)

Abstract

The musculoskeletal system plays a pivotal role in maintaining posture, safeguarding
organs, facilitating flexible movement, and supporting cellular metabolic functions,
thereby enabling active participation in various aspects of life. Conventional
treatment modalities, such as autologous and allogeneic transplantation, face
† These authors contributed equally significant challenges, including donor scarcity, complications, rejection, and
to this work.
infection. The emergence of three-dimensional (3D) bioprinting technology,
*Corresponding author: coupled with bioink sourced from the decellularized extracellular matrix (dECM),
Zeyu Luo (luozy@wchscu.edu.cn)
offers a promising approach for repairing and regenerating musculoskeletal tissue.
Citation: Li P, Li X, Tang G, This article meticulously examines common methods of musculoskeletal tissue
Zhou Z, Luo Z. Emerging frontiers bioprinting, the properties and functions of dECM, techniques for preparing dECM
in 3D bioprinting: Harnessing
decellularized matrix bioink for bioinks, recent advancements, and applications of dECM bioinks in 3D printing of
advancements in musculoskeletal musculoskeletal tissues (e.g., heart, skeletal muscle, tendon, interfaces between
tissue engineering. tissues, bone, and cartilage). The review concludes by delineating current research
Int J Bioprint. 2024;10(5):3418.
doi: 10.36922/ijb.3418 limitations, aiming to catalyze future investigations in this domain.
Received: April 13, 2024
Accepted: June 24, 2024 Keywords: 3D bioprinting; Decellularized extracellular matrix; Bioink;
Published Online: August 21, 2024
Musculoskeletal; Tissue engineering
Copyright: © 2024 Author(s).
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, 1. Introduction
and reproduction in any medium,
provided the original work is The musculoskeletal system, encompassing bones, muscles, cartilage tissue (articular
properly cited. cartilage, intervertebral discs, meniscus), tendons, ligaments, and blood vessels, is
Publisher’s Note: AccScience crucial for maintaining posture, protecting organs, facilitating flexible movement, and
Publishing remains neutral with supporting cellular metabolic functions. Maintaining good musculoskeletal health is
regard to jurisdictional claims in
published maps and institutional essential for people to move with flexibility, work efficiently, and participate actively in
1,2
affiliations. all aspects of life. The World Health Organization (WHO) reports that musculoskeletal

Volume 10 Issue 5 (2024) 68 doi: 10.36922/ijb.3418