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International Journal of Bioprinting Bioprinted plasma biocarriers for MSC delivery

Figure 6. Heat maps comparing the bone marrow-derived mesenchymal stem cell (BMSC) secretome in the presence of IL-1β versus TNF-α. (A)
Canonical pathways associated with inflammation. (B) Canonical pathways associated with nervous system signaling and pain. The dendrograms at the
top of the heatmap illustrate biocarrier clustering based on their differing compositions (i.e., nude, fresh frozen plasma [FFP]-infused, or platelet-rich
plasma [PRP]-infused) and the differences between exposure to either IL-1β or TNF-α. The dendrogram on the left displays three differentiated groups
of canonical pathways activated by inflammatory cytokines. Abbreviations: B1, nude biocarrier exposed to TNF-α; B2, nude biocarrier exposed to IL-1β;
B3, FFP-infused biocarrier exposed to IL-1β; B4, PRP-infused biocarrier exposed to IL-1β; B5, FFP-infused biocarrier exposed to TNF-α; B6, PRP-infused
biocarrier exposed to TNF-α; FFP, fresh frozen plasma; PRP, platelet-rich plasma.

Volume 10 Issue 6 (2024) 310 doi: 10.36922/ijb.4426