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3D Printing Technologies in Metallic Implants
           Table 2. Brief information about the characteristics and outcomes of 3D printed Ti-based porous scaffolds
           AM method      Characteristics                   Results                                 References
           SLM                                              Dimensional accuracy is dependent on printing   [4]
                                                            parameters, such as laser power, scanning speed,
                                                            and  power  layer  thickness. The  10%  porosity
                                                            reduction  results  in  a  100-MPa  increase  in
                         Diamond lattice pore structure, porosity   compression strength. New inward bone tissue
                         66.1 – 79.5%, pore size 0.65 mm, strut   growth  was  observed  in  both  cancellous  and
                         diameter 0.2 – 0.4 mm              compact bone within 0.4 mm strut diameter and
                                                            66.1% porosity
           SLM                                              Well-defined  pore  distribution  with  proper   [119]
                                                            interconnectivity,  the  small  pores  are  helpful
                                                            for cell adhesion, the large pores improve cell

                         Interconnecting  channels  with  various   proliferation. Pores with about 600-μm size are
                         diameters (500, 700, and 900 μm)   beneficial  for  bone  ingrowth,  maturation,  and
                                                            bone-implant fixation stability
           SLM                                              The  TPMS  method  is  suitable  for  obtaining   [120]
                                                            functional graded structures that mimic natural
                                                            bone. Gyroid and diamond unit cells possess a
                         Three gradient patterns (cell size, density,   suitable strength (152.6 MPa and 145.7 MPa)
                         heterostructure),  gyroid  and  diamond   and comparable elastic modulus (3.8 GPa) with
                         unit  cells  with  triply  periodic  minimal   compact bone. The pore size gradient does not
                         surfaces (TPMS)                    lead to considerable density alterations
           SLM                                              TMPS structures well resembled the topological   [121]
                                                            properties  of  trabecular  bone,  high  fatigue
                                                            resistance, and endurance limit as high as 60% of
                                                            their yield stress. It has comparable morphology
                         TPMS  porous  structures,  from  left   and permeability values with trabecular bone.
                         to  right:  primitive,  I-WP,  gyroid,  and   Excellent  mechanical  properties  such  as  low
                         diamond                            elastic modulus and high yield strength
           SLM                                              Other favorable properties are high compressive   [122]
                                                            strength,  improvement  of  bone  integration,
                                                            enhanced  cell  growth,  maximum  calcium
                                                            deposition  in  400  um  pore  size,  and  better
                         Dense  center  and  graded  periphery   osteointegration.  Spider  web  structures  show
                         structure,  porosity  in  the  range  of  50  –   higher Young’s modulus values. Web structures
                         80%                                (70%  porosity)  and  diamond  unit  structures
                                                            (porosity 50%) share almost similar mechanical
                                                            properties
           EBM                                              Porous  structure  minimizes  the  stress-  [123]
                                                            shielding  effect.  Other  beneficial  effects  are
                                                            increased  osteoblasts  function,  cell  adhesion,
                                                            proliferation,  proteins’ function, and calcium
                                                            deposition.  Smaller  pore  sizes  have  better
                                                            biological performance than larger ones






                         Dodecahedron unit cells with various
                         pore  sizes  (600,  400,  and  200  μm).
                         Porosity 65%, with 500 μm strut sizes
                                                                                                       (Contd...)

           36                          International Journal of Bioprinting (2021)–Volume 7, Issue 7
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