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The Role of 3DP Phantoms and Devices for Organ-specified Appliances in Urology
           Table 1. (Continued)
           Organ   Case          Application  3DP        Material     Advantage and    Limitation    References
                                              Technique               Efficacy
           Urethra Urethral injury Urethral model  EM    N/A          •  Understanding   •  Lack of   Joshi and
                                of PFUI                                of complex       material     Kulkarni [71]
                                                                       anatomies of the   information
                                                                       posterior urethra   •  Downscale
                                                                       and other organs  model to 80%
                                                                                        of the size
                   Urethral     In vitro tissue   Bioprinting • PCL/PLCL  •  Multilayer of cell  •  Use of rabbit  Zhang
                   structure    engineered               •  Cell-laden   constructs     cells, instead  et al. [72]
                                urethral model            hydrogel    •  Good cell      of real human
                                                                       viability        cells
                                                                      •  Similarity in
                                                                       mechanical
                                                                       properties of
                                                                       native cells
                   Urethral     Urinary tract   EM       • Mold: PLA  •   Mimicking ability  •  Indirect   Ishii et al.
                   dynamics     phantom for              •  Product:   in urethra’s     fabrication;   [27]
                                urodynamic                PVA cryogel  geometric,       requiring
                                investigations                         mechanical, and   mold
                                                                       hydrodynamic     fabrications
                                                                       characteristics
           Penis   Penile cancer  Penile      VP         Polycarbonate  •  Non-invasive   •  Small sample  D’Alimonte
                                surface mold             -like resin   ambulatory       size for     et al. [74]
                                brachytherapy                          procedure        validation
                                                                      •  Minimal pain
                                                                       during the
                                                                       application
                   Penile       Bio-scaffold   Bioprinting • PCL      •  Well-defined   •  Small sample  Yu et al. [75]
                   reconstruction for tissue             •  Fibroblast   and homogenous   size
                                engineering of            cells        porous structure   •  No
                                penile fibrous                         of the scaffolds  investigation
                                tissue                                •  Good           on the
                                                                       proliferation and   bioavailability
                                                                       differentiation of   of cell-seeded
                                                                       the cells        scaffold in an
                                                                                        in vivo animal
                                                                                        model
           Adrenal Adrenalectomy Phantom for   VP        Translucent   •  No intra-operative  •  Status of the  Srougi
                                pre-surgical             resin         and post-operative   study being   et al. [76]
                                planning                               complications    a single case
                                of partial                            •  Cortisol       report
                                adrenalectomy                          replacement
                                                                       initiation right
                                                                       after surgery


           procedure,  the  duration  of  exposure  to  fluoroscopy   a safe and precise  needle  insertion  into  the  stone
           radiation, and complications. Golab et al. reported their   location.  The  procedure  was  completed  without  any
           experience using a customized 3D-printed surgical guide   complication .
                                                                         [46]
           made of polylactic acid (PLA) for a PNL procedure. The   The size and location of stones are crucial prognostic
           guide  was  designed  with  a  needle  insertion  path  and   parameters in estimating the result of endoscopic stone
           spinous  process  projections  on  its  surface  to  facilitate   removal treatment as well as the possibility of spontaneous


           6                           International Journal of Bioprinting (2021)–Volume 7, Issue 2
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