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Compression Failure of Trabecular Tantalum Scaffolds
           A
















           B















           C

















           Figure 15. 3D and longitudinal section views of finite element analysis results of trabecular Ta scaffolds with porosities of (A) 65%, (B)
           75%, and (C) 85%.
           65 – 85% and 580 – 980 μm, respectively. The porosity   implant  vascularization [42,43] .  Therefore, AM-fabricated
           of human cancellous bone lies in the range 50 – 90% [31,34] .   trabecular Ta scaffolds in this work have suitable porous
           If the porosity of the implant is too small, the ingrowth of   structure characteristics for orthopedic implants.
           new bone and blood vessels will be hindered, which is not   Sufficient yield strength and relatively low elastic
           conducive to the functional reconstruction of the defective   modulus, matched with those of the host bone, are favorable
           bone tissue and the  structural stability  of the  implant.   for enhancing  the long-term  stability  of the implants,
           However, excessive porosity will reduce the mechanical   especially in the load-bearing area. An excessive elastic
           strength of the implant . Studies have shown that porous   modulus leads  to a disproportionate  stress distribution
                             [30]
           Ta scaffolds with porosity in the range 60–85% are not   on  the  implant–bone  interface,  ultimately  resulting  in
           only conducive to cell adhesion, migration, proliferation,   peri-prosthetic  osteolysis  and implant  failure .  As
                                                                                                        [44]
           differentiation, and mineralization but also promote new   listed in Table 2, the yield strength and elastic modulus
           bone ingrowth and vascularization [4,5,7,9] .  The pore size   of  trabecular  Ta  scaffolds  that  underwent  annealing
           of  <1000  μm  facilitates  oxygen  exchange and  nutrient   were in the range 11.9 – 35.7 MPa and 1.1 – 3.0 GPa,
           transportation and enhances the osteoconductivity  and   respectively, and negatively correlated with porosity. The
           osseointegration  of porous implants [39-41] . Moreover,   yield strength and elastic modulus of human cancellous
           pore diameters of >300 μm have been shown to promote   bone  are  in  the  range  6.6  –  36.2  MPa  and  0.88  –  3.4

           122                         International Journal of Bioprinting (2022)–Volume 8, Issue 1
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