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International Journal of Bioprinting 3D printed bioactive dressings for burn wound treatment

Figure 8. Gross examination of wound healing over 28 days (n = 6). Wound images from the control and treatment groups. 3D-printed and non-printed
hydrogels with BBG showed earlier re-epithelization, less necrotic tissue, and smoother wound margins. In contrast, the 3D-printed dressings with porous
contact surface support the non-adhesive removal of wound dressings.
during the 7-day wound coverage. The dry surface of the 3D-printed hydrogel, and 3D-printed hydrogel–BBG20
BBG powder and petrolatum gauze in the control group dressings developed thicker epidermal layer. In contrast,
can only protect the wound from infection and water loss both 3D-printed dressings showed even ER, which
due to evaporation, which results in wound dehydration indicates the positive effect of the porous texture of the
and prolonged healing. 3D-printed contact on tissue regeneration. Despite the
poor wound healing, the BBG powder group showed slight
Figure 10 shows representative H&E-stained slides
obtained from different groups to investigate epidermal regeneration of hair follicles. The non-printed hydrogel–
BBG20 and 3D-printed hydrogel–BBG20 showed the
regeneration (ER), dermal regeneration (DR), and highest regeneration of hair follicles, which shows the
granulation tissue formation (GT), which are key significant effect of BBG on post-burn regeneration of hair
factors in wound healing analysis. The control and follicles. The distinctive regeneration of hair follicles in
non-printed hydrogel groups showed the thickest ER these samples can be due to the continuous hydration and
layer, i.e., hyperkeratosis, which is associated with poor non-adhesive surface with aligned pores. The 3D-printed
skin regeneration. The non-printed hydrogel–BBG20,

Volume 9 Issue 6 (2023) 144 https://doi.org/10.36922/ijb.0118