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Innovative Medicines & Omics Antioxidant nanomedicines for therapies

Table 9. Summary of representative antioxidant nanomedicines for the treatment of skin diseases
Antioxidant nanomedicine Reaction type Disease References
Bilirubin-based nanoparticle Noncatalytic Psoriasis 422-424
CeO nanoparticle in a hydrogel patch Catalytic Atopic dermatitis 431
2
CeO nanoparticle in microneedle Catalytic Androgenetic alopecia 440
2
MnPS nanosheet in microneedle Catalytic Androgenetic alopecia 441
3
CeO nanoparticle in a hydrogel Catalytic Diabetic wound 446
2
MOF-818 nanoparticle in a hydrogel Catalytic Diabetic wound 447
Ru-doped CoSe nanolayer Catalytic Diabetic wound 448
Abbreviation: MOF: Metal-organic framework

Figure 33. Schematic illustration for the construction of MOF-818 nanoparticle-embedded hydrogel for diabetic wound treatment. Reproduced with
permission from Chao et al. Copyright © 2022, American Chemical Society.
447
inflammation, finally leading to septic shock and severe can significantly facilitate the conversion of Ce to Ce
3+
4+
multiple-organ dysfunction. Scavenging ROS is able in CeO (a rate-limiting step during the ROS scavenging
451
2
to alleviate the symptom of sepsis, and antioxidative process ), elevating the whole catalytic efficiency. The
453
nanomedicines are applied to mitigate oxidative stress nanocatalyst was demonstrated to be effective in mitigating
during sepsis treatment. systemic inflammation in two sepsis models. Cao et al.
Soh et al. prepared a Zr-doped CeO nanoparticle for constructed an antioxidant single-atom Co nanocatalyst,
2
catalytic antioxidant treatment of sepsis. The doped Zr in which Co active centers are atomically dispersed on a
452
Volume 1 Issue 1 (2024) 39 doi: 10.36922/imo.2527