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Innovative Medicines & Omics Antioxidant nanomedicines for therapies

A

B

Figure 32. Schematic illustration for the construction of CeO nanoparticle-embedded microneedle (A) and its application in androgenetic alopecia
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treatment (B). Reproduced with permission from Yuan et al. Copyright © 2021, American Chemical Society.
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patch, which shows a high capacity to scavenge perifollicular Ru-doped CoSe nanolayer with an ultrafast and broad-
ROS for facilitating hair regeneration. 441 spectrum catalytic antioxidative activity for treating
diabetic wounds. The Ru atoms with abundant electrons
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11.4. Diabetic wounds treatment and unoccupied orbitals can regulate the electronic state
Diabetic foot ulcer is a typical complication of diabetes, of Co sites and modulate their interaction with oxygen
which leads to an inflammatory and refractory wound that intermediates, thus improving the catalytic properties of
increases the amputation rate of diabetic patients. High nanocatalyst. This work provides an approach of ultrafast
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ROS expression, upregulated pro-inflammatory factors, antioxidation strategy for disease treatment.
hyperglycemia, and vascular lesions are hallmarks of At present, antioxidation nanomedicines are
diabetic foot ulcer microenvironment. In clinic, surgical garnering growing attention in the realm of skin disease
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debridement and glycemic control were used to treat treatment (Table 9). As they are used mainly via topical
diabetic wounds, but suffer from low efficacy as they cannot administration, both capabilities of skin penetration and
alleviate oxidative stress. The high ROS level leads to retention should be investigated to guarantee that they can
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poor proliferation of stem cells and other functional cells, trigger significant antioxidative effect in pathological skins.
largely compromising the repair of diabetic wounds. 445
To solve this issue, Wu et al. prepared a CeO -based 12. Treatments for other diseases
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hydrogel that can initiate catalytic antioxidation reactions In addition to the above applications, antioxidative
in oxidative wound microenvironment, remarkably nanomedicines have also been designed for treating other
accelerating wound healing by facilitating new blood diseases, based on the unique pathological feature of each
vessel growth, oxygen saturation, and skin appendage disease, hopefully to provide feasible therapeutic strategies.
morphogenesis. Chao et al. demonstrated the SOD
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and catalase-like activities of MOF-818 nanoparticles, 12.1. Sepsis treatment
and embedded them in a hydrogel for treating diabetic Sepsis is a systemic inflammatory response syndrome with
wounds (Figure 33). The in vivo model of diabetic rat high morbidity and mortality. It is caused by microbial
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indicates that the antioxidant hydrogel facilitates oxidative infection, which induces endotoxin accumulation,
stress mitigation, angiogenesis, collagen transmission, and triggering excessive inflammatory responses and ROS
re-epithelialization. Very recently, Deng et al. prepared a production. The generated ROS further aggravate
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Volume 1 Issue 1 (2024) 38 doi: 10.36922/imo.2527