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International Journal of Bioprinting 3D bioprinting for lung tissue

Figure 5. The future and challenges of multiscale 3D bioprinting of lung tissue. In the future, advancements in technology will bring forth an array of
enhanced features in the realm of 3D bioprinting. These improvements will include more life-like multiscale lung models, biological models possessing
stretching characteristics, and personalized pathological models. However, it is important to acknowledge that numerous challenges still lie ahead. Created
with BioRender (www.biorender.com).

the bioprinting process, researchers can create material conducting pretrials with artificial lung tissue, the risk
inks that mimic the mechanical microenvironment of the of organ transplantation failure is reduced, and tailored
lung, promoting cell behavior and tissue development that treatment plans can be devised, ultimately improving
closely resemble native lung tissue. patient outcomes. The continuous advancements of 3D
Despite being in its early stages of development, 3D bioprinting research further expand its application in RM,
bioprinting is showing great promise in the field of TE . drug discovery, and personalized healthcare. With further
[97]
Beyond organ printing, 3D bioprinting has multifaceted developments and refinement, the field of medicine has the
applications in medicine, including testing drug delivery potential to undergo a transformative revolution with the
systems and advancing lung disease treatments. Through advent of 3D bioprinting.
the simulation of lung tissue characteristics, it enables Acknowledgments
more accurate assessments of drug delivery and release
efficiency for treating lung diseases . Moreover, by None.
[98]
replicating patients’ lung tissues using 3D bioprinting,
researchers gain valuable insights into the underlying Funding
causes of diverse lung diseases, significantly improving This work was financially supported by the National Natural
disease understanding and fostering the development of Science Foundation of China (52175547 and U21A20337),
novel treatments and medications. An additional benefit China Postdoctoral Science Foundation Special Funded
of 3D bioprinting lies in its ability to create artificial Project (2022T150197), China Postdoctoral Science
lung tissue that precisely matches a patient’s unique Foundation (2021M690938), Henan Province Key R&D,
anatomical structure. This advancement is invaluable in and Promotion Special (Scientific and Technical) Project
predicting organ compatibility and evaluating potential (222102310183 and 222102310141).
outcomes before actual transplantation takes place. By

Volume 9 Issue 6 (2023) 444 https://doi.org/10.36922/ijb.1166