Page 118 - MI-1-1

Microbes & Immunity

CASE SERIES
Klebsiella pneumoniae-related rare multi-site

infections: A case series

Shanshan Jin , Yu Zhang , Lina Zhao , Qiuping Huang , Hui Xie , Jian Lu *,
1†
1†
1
1
1
1
and Ruilan Wang *
1,2
1 Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University,
School of Medicine, Shanghai 200080, China
2 Department of Critical Care Medicine, Shanghai General Hospital of Nanjing Medical University,
Shanghai 200080, China
Abstract
The incidence of Klebsiella pneumoniae (KP)-related rare multi-site infections has
been progressively rising in China, highlighting the need for heightened awareness
of the devastating complications associated with metastatic infections caused by this
bacterium. This article describes the cases of six adult patients diagnosed with KP-related
multi-site infections at a tertiary hospital in China from 2020 to 2022. The cases report
a detailed examination of clinical features, laboratory test findings, bacterial culture
results, imaging examinations, treatments administered, and subsequent outcomes.
Notably, metastatic infections developed in four patients with uncontrolled diabetes.
Despite strict glycemic control and timely antibiotic administration in three patients,
their conditions deteriorated rapidly. The unfavorable prognosis in these patients
† These authors contributed equally
to this work. may be attributed to delayed medical intervention, inadequate diabetes control, and
unattended abscesses. The findings of this case series underscore the importance of
*Corresponding authors:
Ruilan Wang glycemic control, percutaneous abscess drainage, and appropriate antibiotic selection
(wangyusun@hotmail.com) in managing KP infections. Attaining early diagnosis and treatment of KP-related
Jian Lu multi-site infections could potentially enhance patient outcomes.
(lujian@live.cn)
Citation: Jin S, Zhang Y, Zhao L,
et al. Klebsiella pneumoniae- Keywords: Klebsiella pneumoniae; Meningitis; Liver abscess; Metastatic infections;
related rare multi-site infections: A Case report
case series. Microbes & Immunity.
2024;1(1):2600.
doi: 10.36922/mi.2600
Received: December 31, 2023 1. Background
Accepted: February 27, 2024
Klebsiella pneumoniae (KP), an encapsulated gram-negative bacterium, belongs to the
Published Online: March 27, 2024 Enterobacteriaceae family. It was first identified by Carl Friedländer in 1882 as a causative
1
Copyright: © 2024 Author(s). agent of pneumonia. KP, a common opportunistic pathogen, frequently colonizes the
This is an Open-Access article intestinal and urinary tracts. It is a prevalent pathogen responsible for both community-
2
distributed under the terms of the
Creative Commons Attribution acquired and nosocomial infections. Infections caused by KP predominantly affect
License, permitting distribution, diabetic and immunocompromised individuals. 3
and reproduction in any medium,
provided the original work is According to two recent studies, KP strains are divided into several categories:
properly cited. classic KP, hyper-virulent KP (hvKP), carbapenem-resistant hvKP (resulting from the
Publisher’s Note: AccScience acquisition of a multidrug-resistant [MDR] plasmid by a hypervirulent strain), and
Publishing remains neutral with hyper-virulent carbapenem-resistant KP (resulting from the acquisition of a virulence
regard to jurisdictional claims in 4,5
published maps and institutional plasmid by an MDR strain). HvKP strains are notorious for their ability to induce
affiliations. a range of invasive syndromes, such as liver abscesses, pneumonia, urinary tract

Volume 1 Issue 1 (2024) 112 doi: 10.36922/mi.2600