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Table 1. (Continued)
References Device application/research Device material/ Hydrodynamic Main cell type/ Key benefits and
objectives fabrication means mechanism microenvironment enhancements offered by
material the device
Nelson et al. 66 96-well microfluidic human PDMS/ Pipette-induced h-BMSC; h-UVEC; Co-culture in a perfused
bone marrow-on-a-chip soft-lithography flow h-HSPC/collagen-I 3D hydrogel matrix
platform modeling and fibrin matrix
Elucidating endosteal Provides a multi-niche
niche physiology in human microvascularized
bone marrow through a microenvironment
high-throughput platform compared to conventional
that integrates osteogenic, single-niche models,
vascular, and perivascular improving the
microenvironments for understanding of
disease modeling endosteal niche roles
in HSCs maintenance
and radiation response
with high-throughput
reproducibility
Glaser et al. 67 3D human bone marrow PDMS/ Peristaltic pump h-EC; h-HSPC; Perfusable 3D hydrogel
vascularized niche modeling woft-lithography hFOB 1.19; matrix
Unraveling mechanisms h-BMSC/fibrin Provides a more realistic
of human bone marrow hydrogels microenvironment
function and pathological compared to conventional
processes models, improving the
understanding of human
bone marrow function
and drug response with
high spatial and temporal
resolution
Sharipol et al. 68 Modular bone marrow Data not available Peristaltic pump m-BMSC; m-EC; Perfused 3D hydrogel
microenvironment-on-chip m-HSPC/type matrix
modeling I collagen and
Advancing bone marrow fibronectin Provides a more realistic
pathology therapy and modular BMME
through a modular chip compared to conventional
platform that mimics the murine and 2D/3D
vascularized multicellular models, improving the
microenvironment of understanding of bone
functional hematopoietic marrow pathologies,
niches such as marrow failure
syndromes and leukemias,
with an accessible design
for accelerated analysis
Isosaari et al. 69 3D neurovascular Data not available Gravity-induced Human-induced Perfusable 3D hydrogel
network-on-a-chip modeling flow pluripotent stem cell matrix
Unraveling dynamic (hiPSC); h-UVEC; Provides a long-term,
neurovascular human adipose mural cell-integrated
interrelationships stem/stromal cell neurovascular
(ASC); h-BMSC/ microenvironment
collagen-I and fibrin compared to
matrix conventional short-term
models, improving
the mechanistic
understanding of dynamic
intercellular crosstalk
in health and disease
with high-resolution
characterization
(Cont'd...)
Volume 1 Issue 3 (2025) 9 doi: 10.36922/OR025200017
