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Tumor Discovery PTMAP5–hsa-miR-22-3p–KIF2C axis in HCC development

Table 1. (Continued)
Characteristic Low expression of KIF2C (%) High expression of KIF2C (%) P
Histologic grade, n (%) <0.001
G1 38 (10.3) 17 (4.6)
G2 102 (27.6) 76 (20.6)
G3 42 (11.4) 82 (22.2)
G4 3 (0.8) 9 (2.4)
Adjacent hepatic tissue inflammation, n (%) 0.377
None 70 (29.5) 48 (20.3)
Mild 51 (21.5) 50 (21.1)
Severe 11 (4.6) 7 (3)
AFP (ng/mL), n (%) <0.001
≤400 124 (44.3) 91 (32.5)
>400 20 (7.1) 45 (16.1)
Albumin (g/dL), n (%) 1.000
<3.5 37 (12.3) 32 (10.7)
≥3.5 124 (41.3) 107 (35.7)
Prothrombin time, n (%) 0.059
≤4 102 (34.3) 106 (35.7)
>4 55 (18.5) 34 (11.4)
Child-Pugh grade, n (%) 1.000
A 120 (49.8) 99 (41.1)
B 11 (4.6) 10 (4.1)
C 1 (0.4) 0 (0)
Fibrosis Ishak score, n (%) 0.755
0 45 (20.9) 30 (14)
½ 16 (7.4) 15 (7)
— 14 (6.5) 14 (6.5)
5/6 44 (20.5) 37 (17.2)
Vascular invasion, n (%) 0.086
No 117 (36.8) 91 (28.6)
Yes 50 (15.7) 60 (18.9)
Age, median (IQR) 63 (54, 69.5) 60 (51, 67.75) 0.051
Abbreviations: BMI: Body mass index; IQR: Interquartile range; AFP: Alpha-fetoprotein.

the actin cytoskeleton, contributing to the advancement of relationship between KIF2C expression and immune cell
HCC. infiltration dynamics in HCC reveals a notable positive
correlation between KIF2C expression and the infiltration
3.10. Positive correlation between KIF2C expression levels of various immune cell types. These immune
and immune cell infiltration in HCC cell types include B-cells, CD8 T-cells, CD4 T-cells,
+
+
KIF2C, a member of the kinesin-13 family, plays a macrophages, neutrophils, and dendritic cells (Figure S1).
crucial role in the depolymerization of chromosomes and
spindles during mitosis and meiosis, thereby regulating 3.11. Association between KIF2C expression and
the progression of these cellular division phases. In immune cell markers in HCC
HCC, patients with different KIF2C copy numbers did To further explore the role of KIF2C in cancer immunity,
not show notable alterations in immune cell infiltration we examined its association with immune cell marker
levels. However, further investigation into the intricate expression in HCC using the GEPIA tool. The findings

Volume 3 Issue 3 (2024) 11 doi: 10.36922/td.2846